Camilla Luddington stars as Jo Wilson on ABC’s Grey’s Anatomy. Tonight, TV’s longest-running primetime medical drama celebrates 400 episodes with a two-hour season 18 finale starting at 8 PM EDT!

Recipient of the 2007 Golden Globe Award for Best Drama Television Series and nominated for multiple Emmys, including Outstanding Drama Series, Grey’s Anatomy is considered one of the great television shows of our time. The high-intensity medical drama, now in its 18th season, follows Meredith Grey and the team of doctors at Grey Sloan Memorial who are faced with life-or-death decisions daily. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.

Luddington is also known for her voice work and embodiment of Lara Croft in the video game Tomb Raider. For her first starring role in America, she portrayed Kate Middleton in the Lifetime movie, William & Kate. Additional television work includes Californication and True Blood.

I had a lovely discussion with the actress about her character’s powerful evolution, which former character she wishes Jo could’ve been friends with, what she wants Jo’s legacy to be, seeing new generations discover the show, which Grey’s Anatomy quote has stayed with her, and much more!

Watch my full interview below: